Her office had confirmed that the First Lady's procedure was "successful and there were no complications", and that she was on her way to a complete recovery.
US President Donald Trump embraces First Lady Melania Trump (R) during an event in honor of Military Mothers and Spouses in the East Room of the White House in Washington, DC, May 9, 2018.
Mrs. Trump, who has been gradually raising her profile as first lady, recently hosted her first state dinner and launched a public awareness campaign to help children.
The Slovenia-born former model underwent an embolization procedure, said her communications director Stephanie Grisham.
The first lady "will be leaving hospital in 2 or 3 days", Trump said in a tweet Tuesday morning.
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The "treatment of choice" is to cut off the blood supply to shrink the growth, said Dr Lambros Stamatakis of MedStar Washington Hospital Center.
The most likely reason for such a procedure is to treat a benign tumor known as an angiomyolipoma, according to Mohamad Allaf, vice chairman of the urology department at the Johns Hopkins University School of Medicine. He said he expected the first lady back home at the White House before the end of the week. "Thank you for such love and support!" - wrote the President.
The hospitalization comes as Melania Trump, 48, has taken a higher-profile role in the White House in recent weeks.
The president visited her on Monday evening and tweeted that the procedure was "successful" and that his wife was in "good spirits".