The strike was the Egyptian's 32 league goal of the season, the most scored in a 38-game season in the history of the Premier League.
City's free-flowing football, epitomised by Kevin De Bruyne, Leroy Sane, David Silva and Raheem Sterling, had everyone in raptures and in truth, had the title wrapped up several weeks before it was mathematically certain.
Here, AFP Sports looks at what lies ahead for the Premier League's top six.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time victor at Southampton.
Trump's problematic pastor stirs controversy in Jerusalem
And the fact that I and tens of millions of evangelical Christians still believe that is not bigoted and it's not newsworthy. He said that Mormons, Muslims and Hindus "worship a false god", and that Islam is "evil" and " promotes pedophilia ".
"All the other managers deserve this".
Manchester City broke 5 Premier League records this season.
Fans basked in the sunshine in Manchester city centre as Pep Guardiola and his squad travelled along Deansgate and past Albert Square with the Premier League trophy and Carabao Cup. "It's massive. One hundred points is magnificent", BBC Sport quotes Guardiola as saying.
The Brazil goalkeeper, 24, was nominated for the Professional Footballers' Association Young Player of the Year award on the basis of his strong performance this season. The sound of the final whistle was lost amid the din of City's celebrations. "The team is very good together and that's why it's been so special".
Burnley finished a remarkable seventh given their relative lack of financial spending power, behind Chelsea, whose title defence never really got going, and Arsenal, who will now wave goodbye to Wenger after 22 years in charge. Not only must Manchester City ensure that Guardiola is never starved off the kind of players the Spaniard prefers to work with, but the club should also be wary of complacency, especially if they wish to scale the European summit. When I was a little boy I always say England was a little bit like a paradise. "Ultimately, at the end of next season if Pep wins another league that will be a big problem over a three-year period".