The explosions comes a day after a third Friday of protests along the Gaza-Israel border.
According to sources from the Ministry of Health of Gaza, among the injured were civilians who were wounded by Israeli soldiers, as well as people with symptoms of suffocation due to tear gas inhalation.
The troops responded with tear gas and live fire. Others were also injured by rubber-coated steel rounds.
Medics at the scene in the Rafah area said four Palestinians were killed by an Israeli tank shell but an Israeli military spokesman said the army was not involved.
Avoid fake news! Subscribe to the Standard SMS service and receive factual, verified breaking news as it happens. Some in the crowd threw firebombs and an explosive device and tried to cross into Israel, according to the Israeli military.
Palestinian protesters burn an Israeli flag with pictures of US President Donald Trump during clashes with Israeli troops along Gaza's border with israel.
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The Saturday's deaths took the toll to over 30 since the Great March of Return protests erupted on March 30.
The ministry said 419 of them were moved to hospitals and medical centers, and 550 received treatment in field clinics and makeshift hospitals near border areas.
In the northern Gaza Strip, Sumaya Abu Awad, 36, attended the protest with her three daughters and son. "Palestinian women are always at the forefront", she said proudly.
Thousands of Palestinians have arrived at camps near the frontier since March 30 as part of protests calling for Palestinian refugees to return to their former homes that are now inside Israel.
Israel has accused Hamas of using the protests as a cover for carrying out attacks and bringing infiltrators into Israel. Seven were killed in other circumstances, including six militants engaged in apparent attempts to carry out attacks or infiltrate Israel.
But Palestinians said protesters are being shot while posing no threat to soldiers, and United Nations (UN) Secretary-General Antonio Guterres and the European Union had called for an independent investigation. Among those hurt was a Gaza journalist who was shot in the abdomen, the officials said.