Kennedy is seen as a rising star in the party and is a closely watched member of the House Democratic Caucus because of his famous last name and his future ambitions, Politico reported.
Democrat Elizabeth Guzman, the first Hispanic female immigrant elected to the Virginia House of Delegates, will follow Kennedy's response with a speech in Spanish.
"Congressman Kennedy is a relentless fighter for working Americans", said House Minority leader Nancy Pelosi in a statement published Friday, while jointly announcing the decision with the Senate Minority leader Chuck Schumer.
The Massachusetts congressman comes from one of the most prominent families in American politics as the great nephew of former President John F. Kennedy.
SMASH all challenges: North Korea calls for 'REUNIFICATION' with South Korea
We are counting on the fact that he'll see it. "It is more than just regime preservation that we are concerned he will use it for", he said.
The major party in opposition traditionally broadcasts a rebuttal speech following the USA president's annual State of the Union address, which is delivered to a joint session of Congress and sums up achievements and goals. Ted Kennedy, delivered the State of the Union response in 1982.
Guzman, a Democrat and an immigrant from Peru, has said Trump's anti-immigrant rhetoric helped fuel her run for office. Kennedy has been an outspoken liberal voice against the Republican president.
Kennedy's response will not have to do much to eclipse the 2017 Democratic response to President Trump's address to the joint session of Congress.
Speaking to the Boston Globe, Mr Kennedy said: "From healthcare to economic justice to civil rights, the Democratic agenda stands in powerful contrast to President Trump's broken promises to American families".