A $100,000 reward is being offered for a tip that leads to an arrest in the case.
"He didn't think much of it, just thought it was unusual there was a gun in there and gave the bag to a police officer who was in the McDonald's", said Dugan.
A tip about a gun at a McDonald's led to the arrest of 24-year-old Howell Emanuel "Trai" Donaldson III, police announced.
"Somebody stepped up and did the right thing", Tampa Police Chief Brian Dugan said. The co-worker told officer Donaldson handed him the bag and said he was going to leave Florida.
The officer called the operations center, and police determined it was the same gun used in the four murders.
Police in NY said Donaldson had been arrested in May 2014, but the arrest was sealed and no details were available. Monica Hoffa, 32, was shot on October 11, but her body wasn't found until October 13.
"You know, 51 days ago, I said this was a struggle between good and evil", said Tampa Mayor Bob Buckhorn during Tuesday's news conference.
After several hours of questioning, Donaldson was charged with four counts of murder.
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According to Altman, Donaldson is suspected of murdering 22-year-old Benjamin Mitchell, 32-year-old Monica Hoffa, 20-year-old Anthony Naiboa and 60-year-old Ronald Felton in Tampa's Seminole Heights neighborhood.
Tampa police are investigating an incident in Ybor City that may be connected to a recent string of killings in the city.
Citing an arrest affidavit, WTSP reports Donaldson was born in Charlotte, N.C., but graduated form Alonso High School in Tampa.
Donaldson's neighbors said Wednesday that they'd recently seen him playing basketball with his younger brother in the suburban driveway of the family's brick home.
"Tonight is the beginning of when justice will be served".
The murder of 60-year-old Ronald Felton on November 14 as he crossed the street to the food bank where he volunteered twice a week, however, spurred new leads in the case - including additional video footage of a possible suspect.
The four seemingly unconnected victims were separated by age, race and occupation, and each was killed - but not robbed - while walking alone at night within a half-mile area, police said.
Dugan said police believe the person with the firearm was driving that vehicle, but there is no confirmation whether or not it is related to the Seminole Heights murders.