The series might have been sealed already but South Africa reserved their most ruthless performance for the dead rubber in East London on Sunday (October 22) as Bangladesh were subjected to a humiliating 200-run loss.
South Africa posted 369-6 batting first, its highest score against Bangladesh in ODIs, and rolled out the tourists for 169 with almost 10 overs left unbowled at Buffalo Park.
Five of the top six Bangladesh batsmen failed to reach double digit as Bangladesh suffered another big defeat to South Africa in the third and final ODI on Sunday.
In reply, Bangladesh lost their first four wickets for 51 and although Shakib Al Hasan struck eight fours on his way to 63, Sabbir Rahman (39) was the only other batsman to offer any kind of resistance.
Interestingly, Markram swops batting places with Temba Bavuma in the white ball format, meaning Bavuma will actually open the batting with Quinton de Kock. The du Plessis-Markram partnership added 151 runs before the skipper pulled a muscle.
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Debutant Aiden Markram was also impressive, making 66 before being run out once again, just like his debut Test innings against Bangladesh at Senwes Park in Potchefstroom.
Dane Paterson was the pick of the Protea bowlers with 3/44 while Aiden Markram picked up 2/18 and Imran Tahir finished with 2/27.
Useful scores down the order from AB de Villiers (20), Farhaan Behardien (33no) and Kagiso Rabada (23no) propelled South Africa's total to 369.
In response, Bangladesh were shot out for 169 in 40.4 overs. He has been replaced by JP Duminy as skipper in the T20s.
Proteas team manager, Dr Mohammed Moosajee explained: "Faf sustained an acute left lumbar (lower-back) strain while batting and immediately left the field in extreme discomfort".